Scope of the study: Diabetes represents an important risk factor in cases of severe periodontopathies. For elucidating the bidirectional relation existing between the periodontal disease and diabetes, the sanguine variables, known as diabetes risk markers in patients with and without periodontal disease, yet both affected with this metabolic systemic disease, have been studied. Materials and method: Taken into study was a group of 57 patients, divided as follows: group 1 included patients with chronic periodontitis, without systemic diseases (diabetes included), group 2 was formed of patients with chronic periodontitis and diabetes mellitus of type 2. The age of the patients ranged between 35 and 55 years. For all subjects, the periodontal status was evaluated, the levels of the plasmatic lipids were measured, after which a comparative analysis of the two groups was made. Results: Comparatively with the control, the patients with periodontitis and diabetes mellitus showed higher plasmatic levels of total cholesterol, LDL cholesterol and triglycerides. Conclusions: The pro-aterogenic modifications of plasmatic lipids and of blood glucose, manifested in patients suffering from periodontal diseases and diabetes may provide additional proofs on the close association among the periodontal disease, diabetes and the cardiovascular maladies.