Introduction. Prognostication of the postoperative wound healing processes and, further on, of the clinical characteristics of the would-be scar remains topical in modern applied medicine, in particular in maxillo-facial surgery. The goal of the present study is analysis of the dependence of the pathological surgical facial skin scar formation on the dynamics of the PDGF-ВВ content in blood plasma in the early postoperative period. Materials and methods. A clinical study of the relationship between the concentration of the platelet-derived growth factor (ВВ-isoform) in the early postoperative period and the pathological surgical facial skin scar formation was performed on the blood plasma of 128 patients. Results and discussion. During control examination of the patients whose PDGF-ВВ content did not exceed the norm in the early postoperative period after six months, development
of normotrophic surgical facial skin scars was traced in 74 patients (94.8%). In other 4 patients (5.13%), signs of development of hypertrophic surgical scars could be
found. The results of control examination after six months in patients whose PDGF-BB content exceeded the norm and tended to grow in the early postoperative period showed that in 15 patients (88.2%) pathological scars developed, while a normotrophic scar developed only in 2 patients (11.8 %). Conclusions. It has been established that proneness to pathological surgical facial scar formation shows a mutual dependence on the dynamics of the content of the platelet-derived growth factor of ВВ-isoform in blood plasma in the early postoperative period.
- GROWTH FACTORS
- pathological scars